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Functional microRNA targetome undergoes degeneration-induced shift in the retina

BACKGROUND: MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through their association with argonaute 2 (AGO2) - a key member of the RNA Induced Silenci...

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Detalles Bibliográficos
Autores principales: Chu-Tan, Joshua A., Cioanca, Adrian V., Feng, Zhi-Ping, Wooff, Yvette, Schumann, Ulrike, Aggio-Bruce, Riemke, Patel, Hardip, Rutar, Matt, Hannan, Katherine, Panov, Konstantin, Provis, Jan, Natoli, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406976/
https://www.ncbi.nlm.nih.gov/pubmed/34465369
http://dx.doi.org/10.1186/s13024-021-00478-9