Anti-inflammatory effects of saxagliptin and vildagliptin against doxorubicin-induced nephrotoxicity in rats: attenuation of NLRP3 inflammasome up-regulation and tubulo-interstitial injury

BACKGROUND AND PURPOSE: The clinical use of the chemotherapeutic drug, doxorubicin (DXR), is significantly limited by its extensive multi-organ toxicity. Dipeptidyl peptidase-4 (DPP4) is over-expressed in oxidative stress, inflammation and apoptosis. DPP4 inhibitors have proven pleiotropic effects....

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Detalles Bibliográficos
Autores principales: Mostafa, Rasha Ezzat, Morsi, Azza Hassan, Asaad, Gihan Farag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407158/
https://www.ncbi.nlm.nih.gov/pubmed/34522201
http://dx.doi.org/10.4103/1735-5362.323920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407158/
https://www.ncbi.nlm.nih.gov/pubmed/34522201
http://dx.doi.org/10.4103/1735-5362.323920

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