Assessing tumor heterogeneity: integrating tissue and circulating tumor DNA (ctDNA) analysis in the era of immuno-oncology - blood TMB is not the same as tissue TMB

Tissue tumor mutational burden (tTMB) is calculated to aid in cancer treatment selection. High tTMB predicts a favorable response to immunotherapy in patients with non-small cell lung cancer. Blood TMB (bTMB) from circulating tumor DNA is reported to have similar predictive power and has been propos...

Descripción completa

Detalles Bibliográficos
Autores principales: Fridland, Stanislav, Choi, Jaeyoun, Nam, Myungwoo, Schellenberg, Samuel Joseph, Kim, Eugene, Lee, Grace, Yoon, Nathaniel, Chae, Young Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407207/
https://www.ncbi.nlm.nih.gov/pubmed/34462324
http://dx.doi.org/10.1136/jitc-2021-002551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407207/
https://www.ncbi.nlm.nih.gov/pubmed/34462324
http://dx.doi.org/10.1136/jitc-2021-002551

Ejemplares similares