Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

Human cytomegalovirus (HCMV) microRNAs (miRNAs) significantly rewire host signaling pathways to support the viral lifecycle and regulate host cell responses. Here we show that SMAD3 expression is regulated by HCMV miR-UL22A and contributes to the IRF7-mediated induction of type I IFNs and IFN-stimul...

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Detalles Bibliográficos
Autores principales: Pham, Andrew H., Mitchell, Jennifer, Botto, Sara, Pryke, Kara M., DeFilippis, Victor R., Hancock, Meaghan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407580/
https://www.ncbi.nlm.nih.gov/pubmed/34411201
http://dx.doi.org/10.1371/journal.ppat.1009380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407580/
https://www.ncbi.nlm.nih.gov/pubmed/34411201
http://dx.doi.org/10.1371/journal.ppat.1009380

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