Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review

Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening mucocutaneous drug reactions. Several therapies have been used in the treatment of SJS/TEN but none of them have yet been established as the gold standard treatment. Studies have shown that cyclosporine (C...

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Autores principales: Al Rajaibi, Raqiya, Al Rumhi, Thuraiya, Al Abri, Al Mur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407905/
https://www.ncbi.nlm.nih.gov/pubmed/34522420
http://dx.doi.org/10.18295/squmj.4.2021.002
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author Al Rajaibi, Raqiya
Al Rumhi, Thuraiya
Al Abri, Al Mur
author_facet Al Rajaibi, Raqiya
Al Rumhi, Thuraiya
Al Abri, Al Mur
author_sort Al Rajaibi, Raqiya
collection PubMed
description Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening mucocutaneous drug reactions. Several therapies have been used in the treatment of SJS/TEN but none of them have yet been established as the gold standard treatment. Studies have shown that cyclosporine (CsA) can be used off-label in TEN/SJS, which has shown promising therapeutic effectiveness in such diseases. Here we report a 38-year-old woman who presented to Ar Rustaq Hospital, Rustaq, Oman in 2019 with SJS/TEN overlap and was treated successfully with CsA along with supportive management. This case report also includes a literature review on the use of CsA in the treatment of SJS/TEN.
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spelling pubmed-84079052021-09-13 Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review Al Rajaibi, Raqiya Al Rumhi, Thuraiya Al Abri, Al Mur Sultan Qaboos Univ Med J Case Report Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening mucocutaneous drug reactions. Several therapies have been used in the treatment of SJS/TEN but none of them have yet been established as the gold standard treatment. Studies have shown that cyclosporine (CsA) can be used off-label in TEN/SJS, which has shown promising therapeutic effectiveness in such diseases. Here we report a 38-year-old woman who presented to Ar Rustaq Hospital, Rustaq, Oman in 2019 with SJS/TEN overlap and was treated successfully with CsA along with supportive management. This case report also includes a literature review on the use of CsA in the treatment of SJS/TEN. Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2021-08 2021-08-29 /pmc/articles/PMC8407905/ /pubmed/34522420 http://dx.doi.org/10.18295/squmj.4.2021.002 Text en © Copyright 2021, Sultan Qaboos University Medical Journal, All Rights Reserved https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nd/4.0/) .
spellingShingle Case Report
Al Rajaibi, Raqiya
Al Rumhi, Thuraiya
Al Abri, Al Mur
Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review
title Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review
title_full Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review
title_fullStr Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review
title_full_unstemmed Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review
title_short Carbamazepine-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin: Case report and literature review
title_sort carbamazepine-induced stevens-johnson syndrome/toxic epidermal necrolysis overlap treated successfully with oral cyclosporin: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407905/
https://www.ncbi.nlm.nih.gov/pubmed/34522420
http://dx.doi.org/10.18295/squmj.4.2021.002
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