Cargando…

Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity

Chronic high-fat diet (HFD) consumption not only promotes obesity and insulin resistance, but also causes bone loss through mechanisms that are not well understood. Here, we fed wild-type CD-1 mice either chow or a HFD (43% of energy from fat) for 18 weeks; HFD-fed mice exhibited decreased trabecula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sarah, Henneicke, Holger, Cavanagh, Lauryn L., Macfarlane, Eugenie, Thai, Lee Joanne, Foong, Daphne, Gasparini, Sylvia J., Fong-Yee, Colette, Swarbrick, Michael M., Seibel, Markus J., Zhou, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408138/ https://www.ncbi.nlm.nih.gov/pubmed/34465731 http://dx.doi.org/10.1038/s41413-021-00159-9

Ejemplares similares

Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice
por: Henneicke, Holger, et al.
Publicado: (2020)

Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes
por: Gado, Manuel, et al.
Publicado: (2022)

Arthritis and the role of endogenous glucocorticoids
por: Macfarlane, Eugenie, et al.
Publicado: (2020)

The Role of Glucocorticoids in the Management of COVID-19
por: Alexaki, Vasileia Ismini, et al.
Publicado: (2021)

Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
por: Spies, Cornelia M, et al.
Publicado: (2014)

Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
por: Hildebrandt, Susanne, et al.
Publicado: (2018)

SAT-586 Cold-Acclimation Prevents the Onset of Glucocorticoid-Induced Adipose Dysfunction in Male Mice
por: Gado, Manuel M, et al.
Publicado: (2020)

Author Correction: Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo
por: Hildebrandt, Susanne, et al.
Publicado: (2020)

RF21 | PSAT78 The beta3-Adrenergic Receptor as a Target for the Prevention of Glucocorticoid-induced Adipose Tissue Dysfunction in Rodents
por: Gado, Manuel, et al.
Publicado: (2022)

Transgenic disruption of endogenous glucocorticoid signaling in osteoblasts does not alter long-term K/BxN serum transfer-induced arthritis
por: Maleitzke, Tazio, et al.
Publicado: (2023)

Effect of β-ecdysterone on glucocorticoid-induced apoptosis and autophagy in osteoblasts
por: Tang, Yang-Hua, et al.
Publicado: (2018)

Effects of osteoblast autophagy on glucocorticoid-induced femoral head necrosis
por: Zhou, Ming, et al.
Publicado: (2020)

Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation
por: Hardy, Rowan S, et al.
Publicado: (2013)

Glucocorticoids Regulate the Expression of the Human Osteoblastic Endothelin A Receptor Gene
por: Börcsök, Irma, et al.
Publicado: (1998)

Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo
por: Conradie, M M, et al.
Publicado: (2007)

Exacerbation of ozone-induced pulmonary and systemic effects by β(2)-adrenergic and/or glucocorticoid receptor agonist/s
por: Henriquez, Andres R., et al.
Publicado: (2019)

Autophagy relieves the function inhibition and apoptosis-promoting effects on osteoblast induced by glucocorticoid
por: Han, Yudi, et al.
Publicado: (2018)

Loss of the podocyte glucocorticoid receptor exacerbates proteinuria after injury
por: Zhou, Han, et al.
Publicado: (2017)

The Role of MKP-1 in the Anti-Proliferative Effects of Glucocorticoids in Primary Rat Pre-Osteoblasts
por: Sanderson, Micheline, et al.
Publicado: (2015)

Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR
por: Lian, Wei-Shiung, et al.
Publicado: (2018)

Let-7f-5p regulates TGFBR1 in glucocorticoid-inhibited osteoblast differentiation and ameliorates glucocorticoid-induced bone loss
por: Shen, Geng-Yang, et al.
Publicado: (2019)

Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway
por: Lin, Hao, et al.
Publicado: (2014)

Correction: Chaperonin 60 sustains osteoblast autophagy and counteracts glucocorticoid aggravation of osteoporosis by chaperoning RPTOR
por: Lian, Wei-Shiung, et al.
Publicado: (2019)

Use of glucocorticoids in patients with COPD exacerbations in China: a retrospective observational study
por: Zhang, Jing, et al.
Publicado: (2018)

Effects of Empirical Glucocorticoid Use on Severe Acute Exacerbation of COPD During Hospitalization
por: Wu, Ling, et al.
Publicado: (2021)

Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice
por: Beier, Eric E, et al.
Publicado: (2017)

Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts
por: Chen, Liang, et al.
Publicado: (2020)

The Nutraceutical Genistein-Lycopene Combination Improves Bone Damage Induced by Glucocorticoids by Stimulating the Osteoblast Formation Process
por: Mannino, Federica, et al.
Publicado: (2022)

Folate Deficiency Enhanced Inflammation and Exacerbated Renal Fibrosis in High-Fat High-Fructose Diet-Fed Mice
por: Chan, Chun-Wai, et al.
Publicado: (2023)

Deletion of Mesenchymal Glucocorticoid Receptor Attenuates Embryonic Lung Development and Abdominal Wall Closure
por: Li, Aiqing, et al.
Publicado: (2013)

High-Fat Diet Increases Bone Loss by Inducing Ferroptosis in Osteoblasts
por: Zhu, RunJiu, et al.
Publicado: (2022)

Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages
por: Xie, Yufei, et al.
Publicado: (2021)

Glucocorticoid induced group 2 innate lymphoid cell overactivation exacerbates experimental colitis
por: Feng, Bingcheng, et al.
Publicado: (2022)

Flaxseed oil ameliorated high-fat-diet-induced bone loss in rats by promoting osteoblastic function in rat primary osteoblasts
por: Chen, Fulian, et al.
Publicado: (2019)

Alteration of glucocorticoid receptors and exacerbation of inflammation during lytic cytomegalovirus infection in THP‐1 cells
por: Wang, Shujun, et al.
Publicado: (2017)

Airway exposure to perfluorooctanoate exacerbates airway hyperresponsiveness and downregulates glucocorticoid receptor expression in asthmatic mice
por: Zeng, Zeyu, et al.
Publicado: (2021)

ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways
por: Rong, Xing, et al.
Publicado: (2022)

MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin
por: Lian, Wei-Shiung, et al.
Publicado: (2021)

60 years of Cimicifuga racemosa medicinal products: Clinical research milestones, current study findings and current development
por: Henneicke-von Zepelin, Hans-Heinrich
Publicado: (2017)

Porcine induced pluripotent stem cell-derived osteoblast-like cells prevent glucocorticoid-induced bone loss in Lanyu pigs
por: Liao, Yu-Jing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4c6qe14gm8c7lf7vhs35bas2pc