PLK1/vimentin signaling facilitates immune escape by recruiting Smad2/3 to PD-L1 promoter in metastatic lung adenocarcinoma

The prerequisite function of vimentin for the epithelial–mesenchymal transition (EMT) is not clearly elucidated yet. Here, we show that vimentin phosphorylated by PLK1, triggers TGF-β-signaling, which consequently leads to metastasis and PD-L1 expression for immune suppression in lung adenocarcinoma...

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Detalles Bibliográficos
Autores principales: Jang, Hay-Ran, Shin, Sol-Bi, Kim, Chang-Hyeon, Won, Jae-Yeon, Xu, Rong, Kim, Da-Eun, Yim, Hyungshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408167/
https://www.ncbi.nlm.nih.gov/pubmed/33963314
http://dx.doi.org/10.1038/s41418-021-00781-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408167/
https://www.ncbi.nlm.nih.gov/pubmed/33963314
http://dx.doi.org/10.1038/s41418-021-00781-4

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