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Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation
Historical contingency and diminishing returns epistasis have been typically studied for relatively divergent genotypes and/or over long evolutionary timescales. Here, we use Saccharomyces cerevisiae to study the extent of diminishing returns and the changes in the adaptive mutational spectra follow...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408183/ https://www.ncbi.nlm.nih.gov/pubmed/34465770 http://dx.doi.org/10.1038/s41467-021-25440-7 |