A quantitative model predicts how m(6)A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

N(6)-methyladenosine (m(6)A) is a post-transcriptional modification that controls gene expression by recruiting proteins to RNA sites. The modification also slows biochemical processes through mechanisms that are not understood. Using temperature-dependent (20°C–65°C) NMR relaxation dispersion, we s...

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Detalles Bibliográficos
Autores principales: Liu, Bei, Shi, Honglue, Rangadurai, Atul, Nussbaumer, Felix, Chu, Chia-Chieh, Erharter, Kevin Andreas, Case, David A., Kreutz, Christoph, Al-Hashimi, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408185/
https://www.ncbi.nlm.nih.gov/pubmed/34465779
http://dx.doi.org/10.1038/s41467-021-25253-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408185/
https://www.ncbi.nlm.nih.gov/pubmed/34465779
http://dx.doi.org/10.1038/s41467-021-25253-8

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