Cargando…

A quantitative model predicts how m(6)A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions

N(6)-methyladenosine (m(6)A) is a post-transcriptional modification that controls gene expression by recruiting proteins to RNA sites. The modification also slows biochemical processes through mechanisms that are not understood. Using temperature-dependent (20°C–65°C) NMR relaxation dispersion, we s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Bei, Shi, Honglue, Rangadurai, Atul, Nussbaumer, Felix, Chu, Chia-Chieh, Erharter, Kevin Andreas, Case, David A., Kreutz, Christoph, Al-Hashimi, Hashim M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408185/ https://www.ncbi.nlm.nih.gov/pubmed/34465779 http://dx.doi.org/10.1038/s41467-021-25253-8

Ejemplares similares

2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states
por: Abou Assi, Hala, et al.
Publicado: (2020)

Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting
por: Rangadurai, Atul, et al.
Publicado: (2022)

Rapid assessment of Watson–Crick to Hoogsteen exchange in unlabeled DNA duplexes using high-power SELOPE imino (1)H CEST
por: Liu, Bei, et al.
Publicado: (2021)

Probing conformational transitions towards mutagenic Watson–Crick-like G·T mismatches using off-resonance sugar carbon R(1ρ) relaxation dispersion
por: Rangadurai, Atul, et al.
Publicado: (2020)

Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction
por: Shi, Honglue, et al.
Publicado: (2020)

Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?
por: Rangadurai, Atul, et al.
Publicado: (2018)

Insights into Watson–Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m(1)A
por: Sathyamoorthy, Bharathwaj, et al.
Publicado: (2017)

Probing the Hydrogen-Bonding Environment of Individual Bases in DNA Duplexes with Isotope-Edited Infrared Spectroscopy
por: Fick, Robert J., et al.
Publicado: (2021)

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site
por: Chu, Chia-Chieh, et al.
Publicado: (2019)

DNA mismatches reveal conformational penalties in protein-DNA recognition
por: Afek, Ariel, et al.
Publicado: (2020)

5‐Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson–Crick like cmo(5)U‐G Base Pairs
por: Strebitzer, Elisabeth, et al.
Publicado: (2018)

Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing
por: Plangger, Raphael, et al.
Publicado: (2019)

m(6)A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB
por: Chu, Chia-Chieh, et al.
Publicado: (2019)

Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics
por: Merriman, Dawn K., et al.
Publicado: (2018)

Reshaping the research landscape in Brazil
por: Crestana, Gustavo Schiavone, et al.
Publicado: (2023)

Topological constraints in nucleic acid hybridization kinetics
por: Bois, Justin S., et al.
Publicado: (2005)

Epigenetic factor competition reshapes the EMT landscape
por: Al-Radhawi, M. Ali, et al.
Publicado: (2022)

Excited States of Nucleic Acids Probed by Proton Relaxation Dispersion NMR Spectroscopy
por: Juen, Michael Andreas, et al.
Publicado: (2016)

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis
por: Lichtinger, Monika, et al.
Publicado: (2012)

Metastatic breast cancer: Endocrine therapy landscape reshaped
por: Salkeni, Mohamad Adham, et al.
Publicado: (2017)

DNA methylation disruption reshapes the hematopoietic differentiation landscape
por: Izzo, Franco, et al.
Publicado: (2020)

Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape
por: Salguero-Aranda, Carmen, et al.
Publicado: (2020)

Interferons reshape the 3D conformation and accessibility of macrophage chromatin
por: Platanitis, Ekaterini, et al.
Publicado: (2022)

High Performance Virtual Screening by Targeting a High-resolution RNA Dynamic Ensemble
por: Ganser, Laura R., et al.
Publicado: (2018)

Amplifying recombination genome-wide and reshaping crossover landscapes in Brassicas
por: Pelé, Alexandre, et al.
Publicado: (2017)

Impact of Conformational Substates and Energy Landscapes on Understanding Hemoglobin Kinetics and Function
por: Eaton, William A.
Publicado: (2021)

Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem–loop RNAs and their implications for functional cellular assays
por: Kelly, Megan L., et al.
Publicado: (2021)

Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein
por: Gupta, Amar Nath, et al.
Publicado: (2016)

Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
por: Rodríguez-Fdez, Sonia, et al.
Publicado: (2020)

Deficiency of ribosomal proteins reshapes the transcriptional and translational landscape in human cells
por: Luan, Yizhao, et al.
Publicado: (2022)

How directed evolution reshapes energy landscapes in enzymes to boost catalysis
por: Otten, Renee, et al.
Publicado: (2020)

Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico
por: Fleischmann, Jakob, et al.
Publicado: (2021)

The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis
por: Lichtinger, Monika, et al.
Publicado: (2013)

Reshaping the phonon energy landscape of nanocrystals inside a terahertz plasmonic nanocavity
por: Jin, Xin, et al.
Publicado: (2018)

How the COVID-19 Pandemic Is Reshaping the Trade Landscape and What to Do About It
por: Jean, Sébastien
Publicado: (2020)

Coarse Grained Models Reveal Essential Contributions of Topological Constraints to the Conformational Free Energy of RNA Bulges
por: Mustoe, Anthony M., et al.
Publicado: (2014)

2′-O-Trifluoromethylated RNA – a powerful modification for RNA chemistry and NMR spectroscopy
por: Himmelstoß, Maximilian, et al.
Publicado: (2020)

Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides
por: Nauwelaerts, Koen, et al.
Publicado: (2005)

Conformational analysis of nucleic acids revisited: Curves+
por: Lavery, R., et al.
Publicado: (2009)

Kinetics reshape antitumor immunity: Timing, duration, and combination are of importance for successful cancer immunotherapy
por: Jin, Seung Mo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0jtojbd3m9aflmpl85sbfite7m