Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function

High levels of the anti-apoptotic BCL-2 family member MCL-1 are frequently found in breast cancer and, appropriately, BH3-mimetic drugs that specifically target MCL-1’s function in apoptosis are in development as anti-cancer therapy. MCL-1 also has reported non-canonical roles that may be relevant i...

Descripción completa

Detalles Bibliográficos
Autores principales: Campbell, Kirsteen J., Mason, Susan M., Winder, Matthew L., Willemsen, Rosalie B. E., Cloix, Catherine, Lawson, Hannah, Rooney, Nicholas, Dhayade, Sandeep, Sims, Andrew H., Blyth, Karen, Tait, Stephen W. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408186/
https://www.ncbi.nlm.nih.gov/pubmed/33785871
http://dx.doi.org/10.1038/s41418-021-00773-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408186/
https://www.ncbi.nlm.nih.gov/pubmed/33785871
http://dx.doi.org/10.1038/s41418-021-00773-4

Ejemplares similares