PP2Acα promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNFα production

Macrophage accumulation and activation play an essential role in kidney fibrosis; however, the underlying mechanisms remain to be explored. By analyzing the kidney tissues from patients and animal models with kidney fibrosis, we found a large induction of PP2Acα in macrophages. We then generated a m...

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Detalles Bibliográficos
Autores principales: Liang, Yan, Sun, Xiaoli, Wang, Mingjie, Lu, Qingmiao, Gu, Mengru, Zhou, Lu, Hou, Qing, Tan, Mengzhu, Wang, Sudan, Xue, Xian, Dai, Chunsun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408198/
https://www.ncbi.nlm.nih.gov/pubmed/33934104
http://dx.doi.org/10.1038/s41418-021-00780-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408198/
https://www.ncbi.nlm.nih.gov/pubmed/33934104
http://dx.doi.org/10.1038/s41418-021-00780-5

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