Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

p53 is mutated in over half of human cancers. In addition to losing wild-type (WT) tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function (GOF) activity, leading to novel oncogenic phenotypes. To study mutant p53 GOF mechanisms and phenotypes, we genetically enginee...

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Detalles Bibliográficos
Autores principales: Redman-Rivera, Lindsay N., Shaver, Timothy M., Jin, Hailing, Marshall, Clayton B., Schafer, Johanna M., Sheng, Quanhu, Hongo, Rachel A., Beckermann, Kathryn E., Wheeler, Ferrin C., Lehmann, Brian D., Pietenpol, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408227/
https://www.ncbi.nlm.nih.gov/pubmed/34465782
http://dx.doi.org/10.1038/s41467-021-25359-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408227/
https://www.ncbi.nlm.nih.gov/pubmed/34465782
http://dx.doi.org/10.1038/s41467-021-25359-z

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