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USP24 promotes drug resistance during cancer therapy

Drug resistance has remained an important issue in the treatment and prevention of various diseases, including cancer. Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause the tumor genomic instability and cancer stemness, but also i...

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Detalles Bibliográficos
Autores principales: Wang, Shao-An, Young, Ming-Jer, Wang, Yi-Chang, Chen, Shu-Hui, Liu, Chia-Yu, Lo, Yao-An, Jen, Hung-Hsiang, Hsu, Kai-Cheng, Hung, Jan-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408266/
https://www.ncbi.nlm.nih.gov/pubmed/33846536
http://dx.doi.org/10.1038/s41418-021-00778-z