Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase

Here, we provide evidence that high ATP production by the mitochondrial ATP-synthase is a new therapeutic target for anticancer therapy, especially for preventing tumor progression. More specifically, we isolated a subpopulation of ATP-high cancer cells which are phenotypically aggressive and demons...

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Detalles Bibliográficos
Autores principales: Fiorillo, Marco, Scatena, Cristian, Naccarato, Antonio Giuseppe, Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408289/
https://www.ncbi.nlm.nih.gov/pubmed/33986463
http://dx.doi.org/10.1038/s41418-021-00788-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408289/
https://www.ncbi.nlm.nih.gov/pubmed/33986463
http://dx.doi.org/10.1038/s41418-021-00788-x

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