High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo

Mitochondrial transcription factor A (TFAM) is compacting mitochondrial DNA (dmtDNA) into nucleoids and directly controls mtDNA copy number. Here, we show that the TFAM-to-mtDNA ratio is critical for maintaining normal mtDNA expression in different mouse tissues. Moderately increased TFAM protein le...

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Detalles Bibliográficos
Autores principales: Bonekamp, Nina A, Jiang, Min, Motori, Elisa, Garcia Villegas, Rodolfo, Koolmeister, Camilla, Atanassov, Ilian, Mesaros, Andrea, Park, Chan Bae, Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408345/
https://www.ncbi.nlm.nih.gov/pubmed/34462320
http://dx.doi.org/10.26508/lsa.202101034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408345/
https://www.ncbi.nlm.nih.gov/pubmed/34462320
http://dx.doi.org/10.26508/lsa.202101034

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