Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2

STAG2, a component of the mitotically essential cohesin complex, is highly mutated in several different tumour types, including glioblastoma and bladder cancer. Whereas cohesin has roles in many cancer-related pathways, such as chromosome instability, DNA repair and gene expression, the complex natu...

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Detalles Bibliográficos
Autores principales: Bailey, Melanie L, Tieu, David, Habsid, Andrea, Tong, Amy Hin Yan, Chan, Katherine, Moffat, Jason, Hieter, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408347/
https://www.ncbi.nlm.nih.gov/pubmed/34462321
http://dx.doi.org/10.26508/lsa.202101083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408347/
https://www.ncbi.nlm.nih.gov/pubmed/34462321
http://dx.doi.org/10.26508/lsa.202101083

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