Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2
STAG2, a component of the mitotically essential cohesin complex, is highly mutated in several different tumour types, including glioblastoma and bladder cancer. Whereas cohesin has roles in many cancer-related pathways, such as chromosome instability, DNA repair and gene expression, the complex natu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Life Science Alliance LLC
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408347/ https://www.ncbi.nlm.nih.gov/pubmed/34462321 http://dx.doi.org/10.26508/lsa.202101083 |