Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury

Intravenous (IV) infusion of bone marrow‐derived mesenchymal stem/stromal cells (MSCs) stabilizes the blood‐spinal cord barrier (BSCB) and improves functional recovery in experimental models of spinal cord injury (SCI). Although IV delivered MSCs do not traffic to the injury site, IV delivered small...

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Detalles Bibliográficos
Autores principales: Nakazaki, Masahito, Morita, Tomonori, Lankford, Karen L., Askenase, Philip W, Kocsis, Jeffery D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408371/
https://www.ncbi.nlm.nih.gov/pubmed/34478241
http://dx.doi.org/10.1002/jev2.12137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408371/
https://www.ncbi.nlm.nih.gov/pubmed/34478241
http://dx.doi.org/10.1002/jev2.12137

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