Cargando…

Diagnostic Value of the CSF α-Synuclein Real-Time Quaking-Induced Conversion Assay at the Prodromal MCI Stage of Dementia With Lewy Bodies

OBJECTIVE: To investigate whether the CSF α-synuclein (α-syn) real-time quaking-induced conversion (RT-QuIC) assay accurately identifies patients with mild cognitive impairment (MCI) due to probable Lewy body (LB) disease. METHODS: We applied α-syn RT-QuIC to 289 CSF samples obtained from 2 independ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rossi, Marcello, Baiardi, Simone, Teunissen, Charlotte E., Quadalti, Corinne, van de Beek, Marleen, Mammana, Angela, Stanzani-Maserati, Michelangelo, Van der Flier, Wiesje M., Sambati, Luisa, Zenesini, Corrado, Caughey, Byron, Capellari, Sabina, Lemstra, Afina W., Parchi, Piero
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408510/ https://www.ncbi.nlm.nih.gov/pubmed/34210822 http://dx.doi.org/10.1212/WNL.0000000000012438

Ejemplares similares

Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias
por: Baiardi, Simone, et al.
Publicado: (2022)

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression
por: van de Beek, Marleen, et al.
Publicado: (2020)

RT‐QuIC Detection of Pathological α‐Synuclein in Skin Punches of Patients with Lewy Body Disease
por: Mammana, Angela, et al.
Publicado: (2021)

Amyloid-β peptides in cerebrospinal fluid of patients with dementia with Lewy bodies
por: van Steenoven, Inger, et al.
Publicado: (2019)

Neurofilament light chain and α-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes
por: Quadalti, Corinne, et al.
Publicado: (2021)

Diagnostic and prognostic value of cerebrospinal fluid SNAP-25 and neurogranin in Creutzfeldt-Jakob disease in a clinical setting cohort of rapidly progressive dementias
por: Bentivenga, Giuseppe Mario, et al.
Publicado: (2023)

Disease progression in dementia with Lewy bodies: A longitudinal study on clinical symptoms, quality of life and functional impairment
por: van de Beek, Marleen, et al.
Publicado: (2022)

Diagnostic and prognostic performance of CSF α‐synuclein in prion disease in the context of rapidly progressive dementia
por: Mastrangelo, Andrea, et al.
Publicado: (2021)

Diagnostic Accuracy of a Combined Analysis of Cerebrospinal Fluid t-PrP, t-tau, p-tau, and Aβ(42) in the Differential Diagnosis of Creutzfeldt-Jakob Disease from Alzheimer’s Disease with Emphasis on Atypical Disease Variants
por: Abu Rumeileh, Samir, et al.
Publicado: (2016)

Detection of prions in skin punch biopsies of Creutzfeldt–Jakob disease patients
por: Mammana, Angela, et al.
Publicado: (2020)

The Use of Real-Time Quaking-Induced Conversion for the Diagnosis of Human Prion Diseases
por: Poleggi, Anna, et al.
Publicado: (2022)

The CSF neurofilament light signature in rapidly progressive neurodegenerative dementias
por: Abu-Rumeileh, Samir, et al.
Publicado: (2018)

Clinical effects of Lewy body pathology in cognitively impaired individuals
por: Quadalti, Corinne, et al.
Publicado: (2023)

Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature
por: Rossi, Marcello, et al.
Publicado: (2017)

Genetics Contributes to Concomitant Pathology and Clinical Presentation in Dementia with Lewy Bodies
por: van der Lee, Sven J., et al.
Publicado: (2021)

Biomarker testing in MCI patients—deciding who to test
por: van Maurik, Ingrid S., et al.
Publicado: (2021)

Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
por: Chatterjee, Madhurima, et al.
Publicado: (2020)

VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies
por: van Steenoven, Inger, et al.
Publicado: (2019)

Predicting conversion from mild cognitive impairment to Alzheimer's disease using brain (1)H-MRS and volumetric changes: A two- year retrospective follow-up study
por: Mitolo, Micaela, et al.
Publicado: (2019)

Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies
por: Rossi, Marcello, et al.
Publicado: (2020)

Correction to: Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies
por: Rossi, Marcello, et al.
Publicado: (2020)

Grey matter network markers identify individuals with prodromal Alzheimer’s disease who will show rapid clinical decline
por: Pelkmans, Wiesje, et al.
Publicado: (2022)

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies
por: van Steenoven, Inger, et al.
Publicado: (2018)

Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer’s disease
por: Duits, Flora H., et al.
Publicado: (2018)

Phenotypic Heterogeneity of Variably Protease-Sensitive Prionopathy: A Report of Three Cases Carrying Different Genotypes at PRNP Codon 129
por: Baiardi, Simone, et al.
Publicado: (2022)

CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia
por: Abu-Rumeileh, Samir, et al.
Publicado: (2019)

Optimizing cCOG, a Web‐based tool, to detect dementia with Lewy Bodies
por: van Gils, Aniek M., et al.
Publicado: (2022)

Dementia-related genetic variants in an Italian population of early-onset Alzheimer’s disease
por: Bartoletti-Stella, Anna, et al.
Publicado: (2022)

Antemortem CSF Aβ42/Aβ40 ratio predicts Alzheimer's disease pathology better than Aβ42 in rapidly progressive dementias
por: Baiardi, Simone, et al.
Publicado: (2018)

Cognitive effects of Lewy body pathology in clinically unimpaired individuals
por: Palmqvist, Sebastian, et al.
Publicado: (2023)

The Tree-Drawing Test (Koch's Baum Test): A Useful Aid to Diagnose Cognitive Impairment
por: Stanzani Maserati, Michelangelo, et al.
Publicado: (2015)

The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins
por: Rossi, Marcello, et al.
Publicado: (2019)

Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer’s Disease
por: van de Beek, Marleen, et al.
Publicado: (2019)

Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease
por: Hok-A-Hin, Yanaika S., et al.
Publicado: (2023)

Plasma and CSF Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Cross-Sectional and Longitudinal Study
por: Vacchiano, Veria, et al.
Publicado: (2021)

Integrative EEG biomarkers predict progression to Alzheimer's disease at the MCI stage
por: Poil, Simon-Shlomo, et al.
Publicado: (2013)

Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies
por: van de Beek, M., et al.
Publicado: (2020)

Thimet oligopeptidase as a potential CSF biomarker for Alzheimer's disease: A cross‐platform validation study
por: Hok‐A‐Hin, Yanaika S., et al.
Publicado: (2023)

Defining the phenotypic spectrum of sporadic Creutzfeldt–Jakob disease MV2K: the kuru plaque type
por: Baiardi, Simone, et al.
Publicado: (2023)

In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome
por: Giannini, Giulia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9264n7rmdfrkb5htuvhtcnlq1a