Structural and functional interactions between the Ca(2+)-, ATP-, and caffeine-binding sites of skeletal muscle ryanodine receptor (RyR1)

Ryanodine receptor type 1 (RyR1) releases Ca(2+) ions from the sarcoplasmic reticulum of skeletal muscle cells to initiate muscle contraction. Multiple endogenous and exogenous effectors regulate RyR1, such as ATP, Ca(2+), caffeine (Caf), and ryanodine. Cryo-EM identified binding sites for the three...

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Detalles Bibliográficos
Autores principales: Chirasani, Venkat R., Pasek, Daniel A., Meissner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408527/
https://www.ncbi.nlm.nih.gov/pubmed/34352272
http://dx.doi.org/10.1016/j.jbc.2021.101040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408527/
https://www.ncbi.nlm.nih.gov/pubmed/34352272
http://dx.doi.org/10.1016/j.jbc.2021.101040

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