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Structural and functional interactions between the Ca(2+)-, ATP-, and caffeine-binding sites of skeletal muscle ryanodine receptor (RyR1)
Ryanodine receptor type 1 (RyR1) releases Ca(2+) ions from the sarcoplasmic reticulum of skeletal muscle cells to initiate muscle contraction. Multiple endogenous and exogenous effectors regulate RyR1, such as ATP, Ca(2+), caffeine (Caf), and ryanodine. Cryo-EM identified binding sites for the three...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408527/ https://www.ncbi.nlm.nih.gov/pubmed/34352272 http://dx.doi.org/10.1016/j.jbc.2021.101040 |