Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis

Human cytochromes P450(11β) (CYP11B1) and P450(aldo) (CYP11B2) are monooxygenases that synthesize cortisol through steroid 11β-hydroxylation and aldosterone through a three-step process comprising 11β-hydroxylation and two 18-hydroxylations, respectively. CYP11B1 also catalyzes 18-monohydroxylation...

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Detalles Bibliográficos
Autores principales: Mukai, Kuniaki, Sugimoto, Hiroshi, Kamiya, Katsumasa, Suzuki, Reiko, Matsuura, Tomomi, Hishiki, Takako, Shimada, Hideo, Shiro, Yoshitsugu, Suematsu, Makoto, Kagawa, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408562/
https://www.ncbi.nlm.nih.gov/pubmed/34485929
http://dx.doi.org/10.1016/j.crstbi.2021.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408562/
https://www.ncbi.nlm.nih.gov/pubmed/34485929
http://dx.doi.org/10.1016/j.crstbi.2021.08.001

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