The opioid antagonist naltrexone decreases seizure‐like activity in genetic and chemically induced epilepsy models

OBJECTIVE: A significant number of epileptic patients fail to respond to available anticonvulsive medications. To find new anticonvulsive medications, we evaluated FDA‐approved drugs not known to be anticonvulsants. Using zebrafish larvae as an initial model system, we found that the opioid antagoni...

Descripción completa

Detalles Bibliográficos
Autores principales: Sturgeon, Morgan L., Langton, Rachel, Sharma, Shaunik, Cornell, Robert A., Glykys, Joseph, Bassuk, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408599/
https://www.ncbi.nlm.nih.gov/pubmed/34664432
http://dx.doi.org/10.1002/epi4.12512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408599/
https://www.ncbi.nlm.nih.gov/pubmed/34664432
http://dx.doi.org/10.1002/epi4.12512

Ejemplares similares