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Elimination of PknL and MSMEG_4242 in Mycobacterium smegmatis alters the character of the outer cell envelope and selects for mutations in Lsr2

Four serine/threonine kinases are present in all mycobacteria: PknA, PknB, PknG and PknL. PknA and PknB are essential for growth and replication, PknG regulates metabolism, but little is known about PknL. Inactivation of pknL and adjacent regulator MSMEG_4242 in rough colony M. smegmatis mc(2)155 pr...

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Detalles Bibliográficos
Autores principales: Báez-Ramírez, Estalina, Querales, Luis, Aranaga, Carlos Andres, López, Gustavo, Guerrero, Elba, Kremer, Laurent, Carrère-Kremer, Séverine, Viljoen, Albertus, Daffé, Mamadou, Laval, Françoise, Cole, Stewart T., Benjak, Andrej, Alzari, Pedro, André-Leroux, Gwenaëlle, Jacobs, William R., Vilcheze, Catherine, Takiff, Howard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408660/
https://www.ncbi.nlm.nih.gov/pubmed/34485766
http://dx.doi.org/10.1016/j.tcsw.2021.100060