MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a Cochrane Systematic Review

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) causes resistance of tumor cells to alkylating agents. It is a predictive biomarker in high-grade gliomas treated with temozolomide, however, there is no consensus on which test method, methylation sites, and cutoff v...

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Detalles Bibliográficos
Autores principales: Brandner, Sebastian, McAleenan, Alexandra, Kelly, Claire, Spiga, Francesca, Cheng, Hung-Yuan, Dawson, Sarah, Schmidt, Lena, Faulkner, Claire L, Wragg, Christopher, Jefferies, Sarah, Higgins, Julian P T, Kurian, Kathreena M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Metadata Analysis/Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408882/
https://www.ncbi.nlm.nih.gov/pubmed/34467991
http://dx.doi.org/10.1093/neuonc/noab105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408882/
https://www.ncbi.nlm.nih.gov/pubmed/34467991
http://dx.doi.org/10.1093/neuonc/noab105

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