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Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes

Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of thought, action, and emotion. PFC neurons generate top-down goals through recurrent excitatory connections on spines. Thi...

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Detalles Bibliográficos
Autores principales: Woo, Elizabeth, Sansing, Lauren H., Arnsten, Amy F. T., Datta, Dibyadeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408896/
https://www.ncbi.nlm.nih.gov/pubmed/34485797
http://dx.doi.org/10.1177/24705470211029254