Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep

BACKGROUND: Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antagonist (Ra) administration would attenuate brain inflammation and injury in near-...

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Detalles Bibliográficos
Autores principales: Kelly, Sharmony B., Stojanovska, Vanesa, Zahra, Valerie A., Moxham, Alison, Miller, Suzanne L., Moss, Timothy J. M., Hooper, Stuart B., Nold, Marcel F., Nold-Petry, Claudia A., Dean, Justin M., Bennet, Laura, Polglase, Graeme R., Gunn, Alistair J., Galinsky, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408978/
https://www.ncbi.nlm.nih.gov/pubmed/34465372
http://dx.doi.org/10.1186/s12974-021-02238-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408978/
https://www.ncbi.nlm.nih.gov/pubmed/34465372
http://dx.doi.org/10.1186/s12974-021-02238-4

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