A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes

BACKGROUND: Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown. METHODS: We performed a large transcriptome-wide association study (TWAS) leveraging modif...

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Detalles Bibliográficos
Autores principales: Sun, Yanfa, Zhu, Jingjing, Zhou, Dan, Canchi, Saranya, Wu, Chong, Cox, Nancy J., Rissman, Robert A., Gamazon, Eric R., Wu, Lang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408990/
https://www.ncbi.nlm.nih.gov/pubmed/34470669
http://dx.doi.org/10.1186/s13073-021-00959-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408990/
https://www.ncbi.nlm.nih.gov/pubmed/34470669
http://dx.doi.org/10.1186/s13073-021-00959-y

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