Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1

Extra-nodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL) is a highly aggressive lymphoma, in which the tumor suppressor gene PRDM1 is frequently lost or inactivated. We employed two different CRISPR/Cas9 approaches to generate PRDM1-/- primary NK cells to study the role of this gene in N...

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Detalles Bibliográficos
Autores principales: Dong, Gehong, Li, Yuping, Lee, Logan, Liu, Xuxiang, Shi, Yunfei, Liu, Xiaoqian, Bouska, Alyssa, Gong, Qiang, Kong, Lingbo, Wang, Jinhui, Lou, Chih-Hong, McKeithan, Timothy W., Iqbal, Javeed, Chan, Wing C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409030/
https://www.ncbi.nlm.nih.gov/pubmed/32732362
http://dx.doi.org/10.3324/haematol.2020.254276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409030/
https://www.ncbi.nlm.nih.gov/pubmed/32732362
http://dx.doi.org/10.3324/haematol.2020.254276

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