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Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1

Extra-nodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL) is a highly aggressive lymphoma, in which the tumor suppressor gene PRDM1 is frequently lost or inactivated. We employed two different CRISPR/Cas9 approaches to generate PRDM1-/- primary NK cells to study the role of this gene in N...

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Detalles Bibliográficos
Autores principales:	Dong, Gehong, Li, Yuping, Lee, Logan, Liu, Xuxiang, Shi, Yunfei, Liu, Xiaoqian, Bouska, Alyssa, Gong, Qiang, Kong, Lingbo, Wang, Jinhui, Lou, Chih-Hong, McKeithan, Timothy W., Iqbal, Javeed, Chan, Wing C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409030/ https://www.ncbi.nlm.nih.gov/pubmed/32732362 http://dx.doi.org/10.3324/haematol.2020.254276

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