Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPG), within diffuse midline gliomas are aggressive pediatric brain tumors characterized by histone H3-K27M mutation. Small-molecule inhibitors for the EZH2-H3K27 histone methyltransferase have shown promise in preclinical animal models of DIPG, despit...

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Detalles Bibliográficos
Autores principales: Keane, Lily, Cheray, Mathilde, Saidi, Dalel, Kirby, Caoimhe, Friess, Lara, Gonzalez-Rodriguez, Patricia, Gerdes, Maren Elisabeth, Grabert, Kathleen, McColl, Barry W, Joseph, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409254/
https://www.ncbi.nlm.nih.gov/pubmed/34485907
http://dx.doi.org/10.1093/noajnl/vdab096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409254/
https://www.ncbi.nlm.nih.gov/pubmed/34485907
http://dx.doi.org/10.1093/noajnl/vdab096

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