Cargando…

Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPG), within diffuse midline gliomas are aggressive pediatric brain tumors characterized by histone H3-K27M mutation. Small-molecule inhibitors for the EZH2-H3K27 histone methyltransferase have shown promise in preclinical animal models of DIPG, despit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keane, Lily, Cheray, Mathilde, Saidi, Dalel, Kirby, Caoimhe, Friess, Lara, Gonzalez-Rodriguez, Patricia, Gerdes, Maren Elisabeth, Grabert, Kathleen, McColl, Barry W, Joseph, Bertrand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409254/ https://www.ncbi.nlm.nih.gov/pubmed/34485907 http://dx.doi.org/10.1093/noajnl/vdab096

Ejemplares similares

Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
por: Friess, Lara, et al.
Publicado: (2021)

An EZH2 blocker sensitizes histone mutated diffuse midline glioma to cholesterol metabolism inhibitors through an off-target effect
por: Rahal, Farah, et al.
Publicado: (2022)

Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma
por: du Chatinier, Aimée, et al.
Publicado: (2022)

Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma
por: Messinger, Dana, et al.
Publicado: (2022)

The Rules of Engagement: Do Microglia Seal the Fate in the Inverse Relation of Glioma and Alzheimer’s Disease?
por: Cheray, Mathilde, et al.
Publicado: (2019)

Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate
por: Grabert, Kathleen, et al.
Publicado: (2023)

Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients
por: Izquierdo, Elisa, et al.
Publicado: (2021)

STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
por: Zhang, Liang, et al.
Publicado: (2022)

Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time
por: Power, Erica A, et al.
Publicado: (2023)

Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype
por: Saidi, Dalel, et al.
Publicado: (2017)

MRI-guided focused ultrasound blood–brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model
por: Martinez, Payton, et al.
Publicado: (2023)

Multicellular “hotspots” harbor high-grade potential in lower-grade gliomas
por: Kirby, Alastair J, et al.
Publicado: (2021)

A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis
por: Dhar, Swati, et al.
Publicado: (2022)

Parents’ experiences of postmortem tumor donation for high-grade gliomas: benefits and suggested improvements
por: Robertson, Eden G, et al.
Publicado: (2021)

ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
por: González-Rodríguez, Patricia, et al.
Publicado: (2022)

Glioma-associated microglia/macrophages augment tumorigenicity in canine astrocytoma, a naturally occurring model of human glioma
por: Toedebusch, Ryan, et al.
Publicado: (2021)

ET-03 Convection-enhanced delivery of EZH2 inhibitor for the treatment of diffuse midline glioma
por: Sasaki, Takahiro, et al.
Publicado: (2020)

Long-lived tumor-associated macrophages in glioma
por: Georgieva, Petya B, et al.
Publicado: (2020)

Spatial concordance of DNA methylation classification in diffuse glioma
por: Verburg, Niels, et al.
Publicado: (2021)

Environmental and sex-specific molecular signatures of glioma causation
por: Claus, Elizabeth B, et al.
Publicado: (2021)

ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma
por: Jackson, Evangeline R., et al.
Publicado: (2023)

Receptor-driven invasion profiles in diffuse intrinsic pontine glioma
por: Karki, Anju, et al.
Publicado: (2021)

Establishment of patient-derived organoid models of lower-grade glioma
por: Abdullah, Kalil G, et al.
Publicado: (2021)

Distinct metabolic hallmarks of WHO classified adult glioma subtypes
por: Björkblom, Benny, et al.
Publicado: (2022)

Significance of molecular diagnostics for therapeutic decision-making in recurrent glioma
por: Blobner, Jens, et al.
Publicado: (2023)

Comparative drug screening in NUT midline carcinoma
por: Beesley, A H, et al.
Publicado: (2014)

Osteopontin regulates human glioma cell invasiveness and tumor growth in mice
por: Jan, Hsun-Jin, et al.
Publicado: (2010)

High-throughput microRNA profiling of pediatric high-grade gliomas
por: Miele, Evelina, et al.
Publicado: (2014)

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells
por: Lin, Hua, et al.
Publicado: (2017)

Rapid intraoperative molecular genetic classification of gliomas using Raman spectroscopy
por: Livermore, Laurent James, et al.
Publicado: (2019)

Akaluc bioluminescence offers superior sensitivity to track in vivo glioma expansion
por: Bozec, Dominique, et al.
Publicado: (2020)

Comparative evaluation of T-cell receptors in experimental glioma-draining lymph nodes
por: Blobner, Jens, et al.
Publicado: (2021)

MR1 overexpression correlates with poor clinical prognosis in glioma patients
por: Kubica, Phillip, et al.
Publicado: (2021)

An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin
por: Zats, Liat Peretz, et al.
Publicado: (2022)

Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma
por: van Kessel, Emma, et al.
Publicado: (2022)

Dysfunctional dendritic cells limit antigen-specific T cell response in glioma
por: Friedrich, Mirco, et al.
Publicado: (2022)

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells
por: Kim, Ella L., et al.
Publicado: (2010)

Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis
por: Muskens, Ivo S, et al.
Publicado: (2020)

Intracranially injectable multi-siRNA nanomedicine for the inhibition of glioma stem cells
por: Manju, Cheripelil Abraham, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m3hc5p6of068uuqhf0555bqpks