Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer

Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissue...

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Autores principales: Yang, Ziyi, Sun, Haiyan, Ma, Wenlong, Wu, Kai, Peng, Guoyu, Ou, Tong, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409300/
https://www.ncbi.nlm.nih.gov/pubmed/34342940
http://dx.doi.org/10.1002/2211-5463.13262
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author Yang, Ziyi
Sun, Haiyan
Ma, Wenlong
Wu, Kai
Peng, Guoyu
Ou, Tong
Wu, Song
author_facet Yang, Ziyi
Sun, Haiyan
Ma, Wenlong
Wu, Kai
Peng, Guoyu
Ou, Tong
Wu, Song
author_sort Yang, Ziyi
collection PubMed
description Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissues, and its overexpression correlated with poor prognosis. Our transcriptome analysis combined with subsequent functional assays indicated that PLK4 inhibition can suppress BC cell growth and induce cell cycle arrest at G1 phase via activation of the p38/p53/p21 pathway in vitro and in vivo. Overall, our data suggest that PLK4 is a critical regulator of BC cell proliferation, and thus, it may have potential as a novel molecular target for BC treatment.
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spelling pubmed-84093002021-09-03 Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer Yang, Ziyi Sun, Haiyan Ma, Wenlong Wu, Kai Peng, Guoyu Ou, Tong Wu, Song FEBS Open Bio Research Articles Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear. Here, we demonstrate the regulatory function of PLK4 in human BC progression. PLK4 is overexpressed in BC cell lines and tissues, and its overexpression correlated with poor prognosis. Our transcriptome analysis combined with subsequent functional assays indicated that PLK4 inhibition can suppress BC cell growth and induce cell cycle arrest at G1 phase via activation of the p38/p53/p21 pathway in vitro and in vivo. Overall, our data suggest that PLK4 is a critical regulator of BC cell proliferation, and thus, it may have potential as a novel molecular target for BC treatment. John Wiley and Sons Inc. 2021-08-22 /pmc/articles/PMC8409300/ /pubmed/34342940 http://dx.doi.org/10.1002/2211-5463.13262 Text en © 2021 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Yang, Ziyi
Sun, Haiyan
Ma, Wenlong
Wu, Kai
Peng, Guoyu
Ou, Tong
Wu, Song
Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_full Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_fullStr Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_full_unstemmed Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_short Down‐regulation of Polo‐like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
title_sort down‐regulation of polo‐like kinase 4 (plk4) induces g1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409300/
https://www.ncbi.nlm.nih.gov/pubmed/34342940
http://dx.doi.org/10.1002/2211-5463.13262
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