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Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma

Temozolomide (TMZ) resistance is the main challenge in the management of glioma patients. Heparanase can mediate the secretion and function of exosomes, which are considered to be a promising molecular delivery system for cancer therapy. Therefore, this study aimed to investigate whether heparanase‐...

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Detalles Bibliográficos
Autores principales: Si, Jinchao, Li, Wei, Li, Xin, Cao, Lixing, Chen, Zhiqiang, Jiang, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409313/
https://www.ncbi.nlm.nih.gov/pubmed/34036683
http://dx.doi.org/10.1111/cas.14984