Cargando…

PDL1‐positive exosomes suppress antitumor immunity by inducing tumor‐specific CD8(+) T cell exhaustion during metastasis

Metastasis is the main cause of death in individuals with cancer. Immune checkpoint blockade (ICB) can potentially reverse CD8(+) cytotoxic T lymphocytes (CTLs) dysfunction, leading to significant remission in multiple cancers. However, the mechanism underlying the development of CTL exhaustion duri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ji, Song, Yang, Miao, Feng, Chen, Gang, Zhu, Yongjun, Wu, Ning, Pang, Liewen, Chen, Zhiming, Chen, Xiaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409314/ https://www.ncbi.nlm.nih.gov/pubmed/34152672 http://dx.doi.org/10.1111/cas.15033

Ejemplares similares

The prognostic influence of body mass index, resting energy expenditure and fasting blood glucose on postoperative patients with esophageal cancer
por: Wu, Ning, et al.
Publicado: (2016)

A Randomized Control Study on the Efficacy of Thymectomy in Patients with Nonthymomatous (without Chest Tumor) Myasthenia Gravis
por: Chen, Ji, et al.
Publicado: (2020)

The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma
por: Wu, Ning, et al.
Publicado: (2018)

The anti-tumor effects of dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A on inducing autophagy in esophageal squamous cell carcinoma
por: Wu, Ning, et al.
Publicado: (2018)

Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8(+) T cells to demote the antitumor immunity
por: Zhang, Ruochan, et al.
Publicado: (2023)

The Presence of PDL-1 on CD8+ Lymphocytes Is Linked to Survival in Neonatal Sepsis
por: Akhmaltdinova, Lyudmila L., et al.
Publicado: (2022)

Transcriptional suppression of CD8(+) T cell exhaustion for improving T cell immunotherapy
por: Yang, Xue, et al.
Publicado: (2021)

PDL1 shapes the classical Hodgkin lymphoma microenvironment without inducing T-cell exhaustion
por: Taylor, Joseph G., et al.
Publicado: (2022)

Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8(+) progenitor exhausted T cell expansion in tumor models
por: Li, Xiang, et al.
Publicado: (2023)

Blocking TIGIT/CD155 signalling reverses CD8(+) T cell exhaustion and enhances the antitumor activity in cervical cancer
por: Liu, Lu, et al.
Publicado: (2022)

LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGF-β1
por: Miao, Feng, et al.
Publicado: (2019)

PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani
por: Habib, Samar, et al.
Publicado: (2018)

CD8(+) T Cell Exhaustion in Cancer
por: Dolina, Joseph S., et al.
Publicado: (2021)

The Antitumor Effect of Gene-Engineered Exosomes in the Treatment of Brain Metastasis of Breast Cancer
por: Liu, Minchen, et al.
Publicado: (2020)

Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer
por: Hu, Jiaqi, et al.
Publicado: (2021)

A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
por: Lin, Xianbin, et al.
Publicado: (2022)

Regulation of CD8(+) T memory and exhaustion by the mTOR signals
por: Chen, Yao, et al.
Publicado: (2023)

Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects
por: Bai, Haiyan, et al.
Publicado: (2023)

Strategies to reinvigorate exhausted CD8(+) T cells in tumor microenvironment
por: Guan, Qianting, et al.
Publicado: (2023)

Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
por: Li, Hongjun, et al.
Publicado: (2021)

High Levels of Eomes Promote Exhaustion of Anti-tumor CD8(+) T Cells
por: Li, Jing, et al.
Publicado: (2018)

Reconstruction using the colon or jejunum in patients with synchronous advanced esophageal and gastric cancers: a retrospective study from a single institutional database
por: Jiang, Rongrong, et al.
Publicado: (2023)

MGP promotes CD8(+) T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer
por: Rong, Dawei, et al.
Publicado: (2022)

Control of Tumors by Antigen-Specific CD8(+) T Cells through PDL1-Targeted Delivery of Antigenic Peptide
por: Feng, Po-Hao, et al.
Publicado: (2022)

Antithymocyte Globulin Inhibits CD8(+) T Cell Effector Functions via the Paracrine Induction of PDL-1 on Monocytes
por: Copic, Dragan, et al.
Publicado: (2023)

Author Correction: Regulation of CD8(+) T memory and exhaustion by the mTOR signals
por: Chen, Yao, et al.
Publicado: (2023)

PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion
por: Hope, Jennifer L., et al.
Publicado: (2023)

CD39 Expression Identifies Terminally Exhausted CD8(+) T Cells
por: Gupta, Prakash K., et al.
Publicado: (2015)

Synthesis of Novel Peptide Dendrimers PDL-GB2 and PDL-G2
por: Yunzhu, Lin, et al.
Publicado: (2015)

Type 17 immunity promotes the exhaustion of CD8(+) T cells in cancer
por: Kim, Byung-Seok, et al.
Publicado: (2021)

CD8(+) T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma
por: Xu, Chun, et al.
Publicado: (2018)

Exhausted phenotype of circulating CD8(+) T cell subsets in hepatitis B virus carriers
por: Jiang, Daixi, et al.
Publicado: (2022)

Accumulation of exhausted CD8+ T cells in extramammary Paget’s disease
por: Iga, Natsuko, et al.
Publicado: (2019)

TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion
por: Khan, Omar, et al.
Publicado: (2019)

Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
por: Busselaar, Julia, et al.
Publicado: (2020)

Skeletal muscle antagonizes antiviral CD8(+) T cell exhaustion
por: Wu, Jingxia, et al.
Publicado: (2020)

Activation or exhaustion of CD8(+) T cells in patients with COVID-19
por: Rha, Min-Seok, et al.
Publicado: (2021)

Transcriptional regulatory network for the establishment of CD8(+) T cell exhaustion
por: Seo, Wooseok, et al.
Publicado: (2021)

Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells
por: Bannoud, Nadia, et al.
Publicado: (2021)

Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
por: Hussain, Tabinda, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8ub47flcmkue8i7eom13smrmg9