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A novel role of snail in regulating tuberin/AMPK pathways to promote renal fibrosis in the new mouse model of type II diabetes

Epithelial–mesenchymal transition (EMT) plays an important role in tissue fibrosis following chronic exposure to hyperglycemia. This study investigates the role of chronic diabetes in regulating tuberin/snail/AMPK to enhance EMT and increase renal fibrosis. A new mouse model of db/db/TSC2 (+/−) was...

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Detalles Bibliográficos
Autores principales: Liang, Sitai, Yadav, Mukesh, Vogel, Kristine S., Habib, Samy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409551/
https://www.ncbi.nlm.nih.gov/pubmed/34485841
http://dx.doi.org/10.1096/fba.2020-00134