Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2

Remdesivir, a prodrug targeting RNA-dependent-RNA-polymerase, and cyclosporine, a calcineurin inhibitor, individually exerted inhibitory activity against human coronavirus OC43 (HCoV-OC43) in HCT-8 and MRC-5 cells at EC(50) values of 96 ± 34 ∼ 85 ± 23 nM and 2,920 ± 364 ∼ 4,419 ± 490 nM, respectivel...

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Detalles Bibliográficos
Autores principales: Hsu, Hsing-Yu, Yang, Cheng-Wei, Lee, Yue-Zhi, Lin, Yi-Ling, Chang, Sui-Yuan, Yang, Ruey-Bing, Liang, Jian-Jong, Chao, Tai-Ling, Liao, Chun-Che, Kao, Han-Chieh, Wu, Szu-Huei, Chang, Jang-Yang, Sytwu, Huey-Kang, Chen, Chiung-Tong, Lee, Shiow-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409573/
https://www.ncbi.nlm.nih.gov/pubmed/34483914
http://dx.doi.org/10.3389/fphar.2021.706901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409573/
https://www.ncbi.nlm.nih.gov/pubmed/34483914
http://dx.doi.org/10.3389/fphar.2021.706901

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