Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis

Mitochondrial electron transport chain complex I (ETCC1) is the essential core of cancer metabolism, yet potent ETCC1 inhibitors capable of safely suppressing tumor growth and metastasis in vivo are limited. From a plant extract screening, we identified petasin (PT) as a highly potent ETCC1 inhibito...

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Detalles Bibliográficos
Autores principales: Heishima, Kazuki, Sugito, Nobuhiko, Soga, Tomoyoshi, Nishikawa, Masashi, Ito, Yuko, Honda, Ryo, Kuranaga, Yuki, Sakai, Hiroki, Ito, Ryo, Nakagawa, Takayuki, Ueda, Hiroshi, Akao, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409585/
https://www.ncbi.nlm.nih.gov/pubmed/34623325
http://dx.doi.org/10.1172/JCI139933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409585/
https://www.ncbi.nlm.nih.gov/pubmed/34623325
http://dx.doi.org/10.1172/JCI139933

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