PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca(2+) Content

PDE5 (phosphodiesterase 5) inhibition reduces the occurrence of ventricular arrhythmias following myocardial ischemia. However, the mechanisms of the antiarrhythmic effects of PDE5 inhibition are unknown. Diastolic calcium (Ca(2+)) waves lead to arrhythmias by inducing delayed afterdepolarizations (...

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Detalles Bibliográficos
Autores principales: Hutchings, David C., Pearman, Charles M., Madders, George W.P., Woods, Lori S., Eisner, David A., Dibb, Katharine M., Trafford, Andrew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409902/
https://www.ncbi.nlm.nih.gov/pubmed/34247494
http://dx.doi.org/10.1161/CIRCRESAHA.121.318473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409902/
https://www.ncbi.nlm.nih.gov/pubmed/34247494
http://dx.doi.org/10.1161/CIRCRESAHA.121.318473

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