Cargando…

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against α-glucosidase and α-amylase. All synthesised compounds showed potential α-glucosidase and α-amylase inhibitory activities. Compounds 5 g (IC(50): 7.54 ± 1.10 μM), 5e (IC(50): 9.00 ± 0...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Peng-Fei, Xiong, Zhuang, Liao, Cui-ying, Zhang, Xin, Feng, Mei, Wu, Xiao-Zheng, Lin, Jing, Lei, Lin-Sheng, Zhang, You-Cheng, Wang, Shao-Hua, Xu, Xue-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409970/ https://www.ncbi.nlm.nih.gov/pubmed/34459690 http://dx.doi.org/10.1080/14756366.2021.1971976

Ejemplares similares

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
por: Ke, Jun-Jie, et al.
Publicado: (2022)

Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
por: Deng, Xu-Yang, et al.
Publicado: (2022)

Chemical Group Profiling, In Vitro and In Silico Evaluation of Aristolochia ringens on α-Amylase and α-Glucosidase Activity
por: Ahmad, J. B., et al.
Publicado: (2021)

In Vitro and In Silico Evaluation for the Inhibitory Action of O. basilicum Methanol Extract on α-Glucosidase and α-Amylase
por: Shanak, Siba, et al.
Publicado: (2021)

Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-α-Amylase, and Anti-α-Glucosidase: In Vitro and In Silico Approaches
por: Alshehri, Osama M., et al.
Publicado: (2022)

Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors
por: Quan, Nguyen Van, et al.
Publicado: (2019)

Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase
por: Ćorković, Ina, et al.
Publicado: (2022)

Synthesis and Inhibitory Effect of Some Indole‐Pyrimidine Based Hybrid Heterocycles on α‐Glucosidase and α‐Amylase as Potential Hypoglycemic Agents
por: Badria, Farid A., et al.
Publicado: (2019)

In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes
por: Riyaphan, Jirawat, et al.
Publicado: (2021)

West Mexico Berries Modulate α-Amylase, α-Glucosidase and Pancreatic Lipase Using In Vitro and In Silico Approaches
por: Virgen-Carrillo, Carmen Alejandrina, et al.
Publicado: (2022)

Design, Synthesis, In Silico Testing, and In Vitro Evaluation of Thiazolidinone-Based Benzothiazole Derivatives as Inhibitors of α-Amylase and α-Glucosidase
por: Khan, Shoaib, et al.
Publicado: (2022)

Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase
por: Riyaphan, Jirawat, et al.
Publicado: (2018)

Effect of storage time on antioxidant activity and inhibition on α‐Amylase and α‐Glucosidase of white tea
por: Xu, Ping, et al.
Publicado: (2019)

Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds
por: Kalita, Diganta, et al.
Publicado: (2018)

Synthesis and inhibitory activity of N-acetylpyrrolidine derivatives on α-glucosidase and α-amylase
por: Sansenya, Sompong, et al.
Publicado: (2020)

The α-Amylase and α-Glucosidase Inhibition Capacity of Grape Pomace: A Review
por: Cisneros-Yupanqui, Miluska, et al.
Publicado: (2022)

Influence of gallic acid on α-amylase and α-glucosidase inhibitory properties of acarbose
por: Oboh, Ganiyu, et al.
Publicado: (2016)

A Review of the In Vitro Inhibition of α-Amylase and α-Glucosidase by Chalcone Derivatives
por: Tran, Thanh-Dao, et al.
Publicado: (2023)

Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies
por: Nguyen, Tan Khanh, et al.
Publicado: (2023)

Spiroindolone Analogues as Potential Hypoglycemic with Dual Inhibitory Activity on α-Amylase and α-Glucosidase
por: Altowyan, Mezna Saleh, et al.
Publicado: (2019)

α-Glucosidase, α-Amylase and Antioxidant Evaluations of Isolated Bioactives from Wild Strawberry
por: Huneif, Mohammed A., et al.
Publicado: (2022)

Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review
por: Wang, Xiaojing, et al.
Publicado: (2022)

Different Proportions of Huangqi (Radix Astragali Mongolici) and Honghua (Flos Carthami) Injection on α-Glucosidase and α-Amylase Activities
por: Liao, Hui, et al.
Publicado: (2015)

In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract
por: Ganeshpurkar, Aditya, et al.
Publicado: (2013)

Modes of Inhibition of α-Amylase and α-Glucosidase by Aqueous Extract of Morinda lucida Benth Leaf
por: Kazeem, M. I., et al.
Publicado: (2013)

In vitro α-amylase and α-glucosidase inhibitory effects and cytotoxic activity of Albizia antunesiana extracts
por: Chipiti, Talent, et al.
Publicado: (2015)

In Vitro Inhibition of α-Amylase and α-Glucosidase by Extracts from Psiadia punctulata and Meriandra bengalensis
por: Kidane, Yosief, et al.
Publicado: (2018)

The α-amylase and α-glucosidase inhibitory activities of the dichloromethane extracts and constituents of Ferulago bracteata roots
por: Karakaya, Songül, et al.
Publicado: (2017)

Investigation into the Thermal Response and Pharmacological Activity of Substituted Schiff Bases on α-Amylase and α-Glucosidase
por: Okoli, Bamidele Joseph, et al.
Publicado: (2018)

Antioxidant, α-Amylase and α-Glucosidase Inhibitory Activities and Potential Constituents of Canarium tramdenum Bark
por: Quan, Nguyen Van, et al.
Publicado: (2019)

In Vitro Inhibitory Effects of Organic Acids Identified in Commercial Vinegars on α-Amylase and α-Glucosidase
por: Noh, Young-Hee, et al.
Publicado: (2020)

In vitro and in vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymes
por: Agada, Reuben, et al.
Publicado: (2020)

Inhibitors of α‐amylase and α‐glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia
por: Gong, Lingxiao, et al.
Publicado: (2020)

Phytochemical Screening, Antioxidant, and Inhibition Activity of Picrorhiza kurroa Against α-Amylase and α-Glucosidase
por: Nisar, Jaweria, et al.
Publicado: (2022)

Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents
por: Niri, Davood Rezapour, et al.
Publicado: (2022)

In vitro inhibitory effects of plant-based foods and their combinations on intestinal α-glucosidase and pancreatic α-amylase
por: Adisakwattana, Sirichai, et al.
Publicado: (2012)

Development of an antidiabetic formulation (ADJ6) and its inhibitory activity against α-amylase and α-glucosidase
por: Duraiswamy, Anand, et al.
Publicado: (2015)

Antidiabetic potential of Asparagus racemosus Willd leaf extracts through inhibition of α-amylase and α-glucosidase
por: Vadivelan, R., et al.
Publicado: (2018)

Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities
por: Kiem, Phan Van, et al.
Publicado: (2020)

Linking the Phytochemicals and the α-Glucosidase and α-Amylase Enzyme Inhibitory Effects of Nigella sativa Seed Extracts
por: Tiji, Salima, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5hsjn1hlapu0vmo1ij7d81adpj