Cargando…
Naive infection predicts reservoir diversity and is a formidable hurdle to HIV eradication
Historically, naive cells have been considered inconsequential to HIV persistence. Here, we compared the contributions of naive and memory cells to the reservoirs of individuals with a spectrum of reservoir sizes and variable immunological control. We performed proviral sequencing of approximately 6...
Autores principales: | Pinzone, Marilia R., Weissman, Sam, Pasternak, Alexander O., Zurakowski, Ryan, Migueles, Stephen, O’Doherty, Una |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409977/ https://www.ncbi.nlm.nih.gov/pubmed/34228640 http://dx.doi.org/10.1172/jci.insight.150794 |
Ejemplares similares
-
Persistence of an intact HIV reservoir in phenotypically naive T cells
por: Venanzi Rullo, Emmanuele, et al.
Publicado: (2020) -
Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained
por: Pinzone, Marilia Rita, et al.
Publicado: (2018) -
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
por: Pinzone, Marilia Rita, et al.
Publicado: (2019) -
Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs
por: Baxter, Amy E., et al.
Publicado: (2018) -
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies
por: Eriksson, Susanne, et al.
Publicado: (2013)