Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome

The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane (NM) ruptures, DNA damage, and cell death in cult...

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Detalles Bibliográficos
Autores principales: Kim, Paul H., Chen, Natalie Y., Heizer, Patrick J., Tu, Yiping, Weston, Thomas A., Fong, Jared L.-C., Gill, Navjot Kaur, Rowat, Amy C., Young, Stephen G., Fong, Loren G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409987/
https://www.ncbi.nlm.nih.gov/pubmed/34423791
http://dx.doi.org/10.1172/jci.insight.151515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409987/
https://www.ncbi.nlm.nih.gov/pubmed/34423791
http://dx.doi.org/10.1172/jci.insight.151515

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