Cargando…

PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization

The γδ T cell is a promising candidate cell in tumor immunotherapy. However, γδ T cells polarize to CD39(+)γδ Tregs upon colorectal cancer (CRC) induction, and the underlying mechanism remains unclear. Here, we show that the frequency of CD39(+)γδ Tregs, which positively correlated with poor prognos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhan, Yang, Zheng, Lei, Liu, Jia, Hu, Dongzhi, Wang, Junfeng, Liu, Kai, Guo, Jiansheng, Zhang, Ti, Kong, Dalu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409991/ https://www.ncbi.nlm.nih.gov/pubmed/34283812 http://dx.doi.org/10.1172/jci.insight.148028

Ejemplares similares

Circulating CD4(+) Treg, CD8(+) Treg, and CD3(+) γδ T Cell Subpopulations in Ovarian Cancer
por: Li, Rong, et al.
Publicado: (2023)

Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin
por: Yang, Xia, et al.
Publicado: (2018)

Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome
por: Yang, Xinyu, et al.
Publicado: (2021)

Rapamycin Regulates iTreg Function through CD39 and Runx1 Pathways
por: Lu, Yunjie, et al.
Publicado: (2014)

Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis
por: Liu, Jia, et al.
Publicado: (2020)

Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells
por: Ni, Chao, et al.
Publicado: (2020)

Decreased Frequency of Intestinal CD39(+) γδ(+) T Cells With Tissue-Resident Memory Phenotype in Inflammatory Bowel Disease
por: Libera, Jana, et al.
Publicado: (2020)

Tissue-Specific Expression of TIGIT, PD-1, TIM-3, and CD39 by γδ T Cells in Ovarian Cancer
por: Weimer, Pauline, et al.
Publicado: (2022)

CD8+CD103+ iTregs Inhibit Chronic Graft-versus-Host Disease with Lupus Nephritis by the Increased Expression of CD39
por: Zhang, Xiao, et al.
Publicado: (2019)

Use of Tregs as a cell‐based therapy via CD39 for benign prostate hyperplasia with inflammation
por: Jin, Xi, et al.
Publicado: (2020)

Inversed Ratio of CD39/CD73 Expression on γδ T Cells in HIV Versus Healthy Controls Correlates With Immune Activation and Disease Progression
por: Kolbe, Katharina, et al.
Publicado: (2022)

Expression of CD39 Is Correlated With HIV DNA Levels in Naïve Tregs in Chronically Infected ART Naïve Patients
por: Song, Jin-Wen, et al.
Publicado: (2019)

Expression of the cancer stem cell markers ABCG2 and OCT-4 in right-sided colon cancer predicts recurrence and poor outcomes
por: Hu, Jun, et al.
Publicado: (2017)

Cyclin-dependent kinase 9 expression and its association with CD8(+) T cell infiltration in microsatellite-stable colorectal cancer
por: Wang, Jiefu, et al.
Publicado: (2019)

The dark side of Tregs during aging
por: Palatella, Martina, et al.
Publicado: (2022)

Mass Cytometry Discovers Two Discrete Subsets of CD39(−)Treg Which Discriminate MGUS From Multiple Myeloma
por: Marsh-Wakefield, Felix, et al.
Publicado: (2019)

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin
por: Zarin, Payam, et al.
Publicado: (2023)

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs
por: Bowakim-Anta, Natalia, et al.
Publicado: (2023)

LPS-Treated Podocytes Polarize Naive CD4(+) T Cells into Th17 and Treg Cells
por: Yuan, Da-Hai, et al.
Publicado: (2020)

γδ TCR Recognition of MR1: Adapting to Life on the Flip Side
por: Willcox, Benjamin E., et al.
Publicado: (2020)

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers
por: Talhouni, Shahd, et al.
Publicado: (2023)

Hepatitis B envelope antigen increases Tregs by converting CD4+CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) Tregs
por: Tang, Rui, et al.
Publicado: (2020)

In Vivo Dynamical Interactions between CD4 Tregs, CD8 Tregs and CD4(+)CD25(−) Cells in Mice
por: Arazi, Arnon, et al.
Publicado: (2009)

A Functional γδTCR/CD3 Complex Distinct from γδT Cells Is Expressed by Human Eosinophils
por: Legrand, Fanny, et al.
Publicado: (2009)

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127(pos) Depletion, Treg Expansion, and Treg Cryopreservation
por: Peters, Jorieke H., et al.
Publicado: (2008)

CD4(+)CCR8(+) Tregs in ovarian cancer: a potential effector Tregs for immune regulation
por: Liu, Shuna, et al.
Publicado: (2023)

Expression of CD27 and CD28 on γδ T cells from the peripheral blood of patients with allergic rhinitis
por: Wang, Qiong, et al.
Publicado: (2020)

CD39 Regulation and Functions in T Cells
por: Timperi, Eleonora, et al.
Publicado: (2021)

Difference between CD25(+)Tregs and Helios(+)Tregs in a murine model of allergic rhinitis
por: Wang, Yun-Xiu, et al.
Publicado: (2020)

Review immune response of targeting CD39 in cancer
por: Liu, Yao, et al.
Publicado: (2023)

Laparoscopic Surgery Within an Enhanced Recovery after Surgery (ERAS) Protocol Reduced Postoperative Ileus by Increasing Postoperative Treg Levels in Patients with Right-Side Colon Carcinoma
por: Wang, Honggang, et al.
Publicado: (2018)

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors
por: Schäkel, Laura, et al.
Publicado: (2020)

Pro-tumor γδ T Cells in Human Cancer: Polarization, Mechanisms of Action, and Implications for Therapy
por: Chabab, Ghita, et al.
Publicado: (2020)

The Role of Cluster of Differentiation 39 (CD39) and Purinergic Signaling Pathway in Viral Infections
por: Elsaghir, Alaa, et al.
Publicado: (2023)

MicroRNA‐143‐3p ameliorates collagen‐induced arthritis by polarizing naive CD4 (+)T cells into Treg cells
por: Shen, Mei‐Yu, et al.
Publicado: (2023)

Activation-induced Modification in the CD3 Complex of the γδ T Cell Receptor
por: Hayes, Sandra M., et al.
Publicado: (2002)

Roles of the Adenosine Receptor and CD73 in the Regulatory Effect of γδ T Cells
por: Liang, Dongchun, et al.
Publicado: (2014)

CD161 expression defines new human γδ T cell subsets
por: Karunathilaka, Amali, et al.
Publicado: (2022)

CD8(+)脾脏γδT细胞淋巴瘤1例
Publicado: (2023)

Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection
por: Thorborn, Georgina, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_j4g8230bn0op898ngsoo2755kr