Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production

Thyroid hormone receptor β (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupted sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues. The THRB K146Q mutant mice had...

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Detalles Bibliográficos
Autores principales: Ke, Sujie, Liu, Yan-Yun, Karthikraj, Rajendiran, Kannan, Kurunthachalam, Jiang, Jingjing, Abe, Kiyomi, Milanesi, Anna, Brent, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410017/
https://www.ncbi.nlm.nih.gov/pubmed/34237030
http://dx.doi.org/10.1172/jci.insight.149425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410017/
https://www.ncbi.nlm.nih.gov/pubmed/34237030
http://dx.doi.org/10.1172/jci.insight.149425

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