RTEC-intrinsic IL-17–driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1

Antibody-mediated glomerulonephritis (AGN) is a clinical manifestation of many autoimmune kidney diseases for which few effective treatments exist. Chronic inflammatory circuits in renal glomerular and tubular cells lead to tissue damage in AGN. These cells are targeted by the cytokine IL-17, which...

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Detalles Bibliográficos
Autores principales: Li, De-Dong, Bechara, Rami, Ramani, Kritika, Jawale, Chetan V., Li, Yang, Kolls, Jay K., Gaffen, Sarah L., Biswas, Partha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410033/
https://www.ncbi.nlm.nih.gov/pubmed/34236049
http://dx.doi.org/10.1172/jci.insight.147505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410033/
https://www.ncbi.nlm.nih.gov/pubmed/34236049
http://dx.doi.org/10.1172/jci.insight.147505

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