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Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8(+) T cells
T cell receptor (TCR) stimulation leads to the expression of the transcription factor thymocyte selection–associated high-mobility group box (TOX). Prolonged TCR signaling, such as encountered during chronic infections or in tumors, leads to sustained TOX expression, which is required for the induct...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410038/ https://www.ncbi.nlm.nih.gov/pubmed/34032638 http://dx.doi.org/10.1172/jci.insight.150744 |