Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair–deficient colorectal cancer tissue

Although CD8(+) T cells recognize neoantigens that arise from somatic mutations in cancer, only a small fraction of nonsynonymous mutations give rise to clinically relevant neoantigens. In this study, HLA class I ligandomes of a panel of human colorectal cancer (CRC) and matched normal tissues were...

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Detalles Bibliográficos
Autores principales: Hirama, Tomomi, Tokita, Serina, Nakatsugawa, Munehide, Murata, Kenji, Nannya, Yasuhito, Matsuo, Kazuhiko, Inoko, Hidetoshi, Hirohashi, Yoshihiko, Hashimoto, Shinichi, Ogawa, Seishi, Takemasa, Ichiro, Sato, Noriyuki, Hata, Fumitake, Kanaseki, Takayuki, Torigoe, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410045/
https://www.ncbi.nlm.nih.gov/pubmed/34185709
http://dx.doi.org/10.1172/jci.insight.146356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410045/
https://www.ncbi.nlm.nih.gov/pubmed/34185709
http://dx.doi.org/10.1172/jci.insight.146356

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