JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer

The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-Ras(G12D)–induced lung adenocarcinoma, we inducibly deleted c-Jun in the adult lung. Surprisingly...

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Detalles Bibliográficos
Autores principales: Ruiz, E. Josue, Lan, Linxiang, Diefenbacher, Markus Elmar, Riising, Eva Madi, Da Costa, Clive, Chakraborty, Atanu, Hoeck, Joerg D., Spencer-Dene, Bradley, Kelly, Gavin, David, Jean-Pierre, Nye, Emma, Downward, Julian, Behrens, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410048/
https://www.ncbi.nlm.nih.gov/pubmed/34236045
http://dx.doi.org/10.1172/jci.insight.124985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410048/
https://www.ncbi.nlm.nih.gov/pubmed/34236045
http://dx.doi.org/10.1172/jci.insight.124985

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