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JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer

The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-Ras(G12D)–induced lung adenocarcinoma, we inducibly deleted c-Jun in the adult lung. Surprisingly...

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Detalles Bibliográficos
Autores principales:	Ruiz, E. Josue, Lan, Linxiang, Diefenbacher, Markus Elmar, Riising, Eva Madi, Da Costa, Clive, Chakraborty, Atanu, Hoeck, Joerg D., Spencer-Dene, Bradley, Kelly, Gavin, David, Jean-Pierre, Nye, Emma, Downward, Julian, Behrens, Axel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410048/ https://www.ncbi.nlm.nih.gov/pubmed/34236045 http://dx.doi.org/10.1172/jci.insight.124985

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